megalomaniac -
Someone who has an unnaturally strong wish for power and control.
The dictator showed signs of being a megalomaniac even as a child, the way he bossed everyone around in the schoolyard.
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delusional -
Seeing or believing things that are not real
Betty was confident that she would be a millionaire by the time she would be 25, but her friends thought she was delusional.
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nuts -
Crazy, insane, or stupid, often in a humorous way
Bill's friends thought he was nuts for swimming in the middle of the winter.
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catatonic -
Appearing to be in a daze or stupor; unresponsive, not moving or reacting.
His experiment with psychodelics left him in a catatonic state where he showed almost no emotion, and it that took years for him to recover.
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deranged -
Behaving in an uncontrolled or dangerous way because of mental illness
Charles Manson led a group of followers who became mentally deranged as a result of taking too many psychedelic drugs
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loony -
Crazy or silly
The patients in the mental hospital could be described as loony, but the doctors tried to treat them as normal human beings with normal problems in order to try to help them get better.
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hysterical -
Having uncontrolled extreme emotion
When Amy found out that her house had been destroyed by the tornado, she broke down into hysterical crying, and could not be comforted for hours.
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zany -
Amusingly unconventional and different
Einstein was unique among geniuses in that he also had a silly and zany side of his personality.
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weirdo -
A person whose dress or behavior seems strange
The weirdo kept peeking at everyone from behind the bushes.
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wacky -
Something that is strange and different to the point of amusement.
George’s grandmother was well known and loved for her wacky taste in shoes.
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daffy -
Silly, different, strange, and funny
Fred had a twirled mustache and wore an oddly colored suit, but the town's residents simply viewed him as daffy instead of someone to be afraid of.
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crank -
Someone who others think has unusual ideas or behaves strangely
Bill was seen as crank by his friends, because of the way he always spoke of the dangers of eating meat and being vaccinated.