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megalomaniac - Someone who has an unnaturally strong wish for power and control.

The dictator showed signs of being a megalomaniac even as a child, the way he bossed everyone around in the schoolyard.

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bonkers - Mentally unbalanced, mad and crazy, usually meant humorously

There were many long stretches of time that Joan was cooped up in the house with her kids, and it was making her go bonkers.

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maniac - Someone who is mentally ill tending towards violent and dangerous behavior.

The film’s villain was portrayed as a ruthless maniac with no regard for human life.

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lunatic - A person who is crazy

Martha was a defensive driver, to be safer with regards to a possible lunatic behind the wheel of another car.

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delirious - In a disturbed state of mind, often due to illness or fever, leading to confusion and hallucinations.

After three sleepless nights, he was delirious and barely able to speak clearly.

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cantankerous - Bad-tempered, argumentative, and uncooperative

The constant arguing of the cantankerous couple living above Ann always kept her up at night.

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hysterical - Having uncontrolled extreme emotion

When Amy found out that her house had been destroyed by the tornado, she broke down into hysterical crying, and could not be comforted for hours.

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delusional - Seeing or believing things that are not real

Betty was confident that she would be a millionaire by the time she would be 25, but her friends thought she was delusional.

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wacky - Something that is strange and different to the point of amusement.

George’s grandmother was well known and loved for her wacky taste in shoes.

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nuts - Crazy, insane, or stupid, often in a humorous way

Bill's friends thought he was nuts for swimming in the middle of the winter.

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crank - Someone who others think has unusual ideas or behaves strangely

Bill was seen as crank by his friends, because of the way he always spoke of the dangers of eating meat and being vaccinated.

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deranged - Behaving in an uncontrolled or dangerous way because of mental illness

Charles Manson led a group of followers who became mentally deranged as a result of taking too many psychedelic drugs