plight - A difficult or unfortunate situation, often one that involves hardship or adversity.

angst - A feeling of deep anxiety or dread, typically an unfocused one about the human condition or the state of the world in general

cramps - A painful, involuntary contraction of muscles

inflammation - A physical condition characterized by redness, heat, swelling, and pain, often as a response to injury or infection.

shackles - A device, such as a chain or cuff, designed to physically limit or control a person or thing's movement.