degenerate -
To decline or deteriorate physically, mentally, or morally
After Bill started taking drugs, his life went downhill until his his relationships, health, and finances had totally degenerated.
adjective
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excruciating -
Intensely painful
Becky had to see the dentist because her toothache was causing her excruciating pain.
noun
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angst -
A feeling of deep anxiety or dread, typically an unfocused one about the human condition or the state of the world in general
Edvard Munch's famous painting, "The Scream," is often viewed as an expression of angst in an uncertain world.
noun
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anguish -
Severe mental or physical pain or suffering
With her personal and professional life in disarray, Jenny's anguish was often too much for her to bear.
adjective
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afflicted -
Suffering from a serious problem, illness, or pain, be it mental or physical.
Many people are afflicted with anxiety in high-pressure situations.
noun
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inflammation -
A physical condition characterized by redness, heat, swelling, and pain, often as a response to injury or infection.
The redness of the big toe was caused by an infection, and the inflammation was visible and painful.
verb
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flinch -
To make a quick, nervous movement of the face or body as an instinctive reaction to surprise, fear or pain
Debbie was very brave and didn’t flinch when the nurse put the needle in her arm to give her the flu shot.
noun
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hardship -
Severe suffering or difficulty caused by lack of necessities like food, money, or shelter.
Many families are facing economic hardship due to rising living costs.
adjective
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agonizing -
Something that causes great physical or mental pain.
After she took the final exam, it was agonizing to her that for a whole week she wouldn't find out the results.
noun
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throes -
Intense or violent pain and struggle, especially accompanying birth, death, or great change
Samantha experienced agonizing pain during the throes of childbirth.
noun
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pang -
A sudden sharp pain or painful emotion
The year was 1900, and Dmitri felt a pang of nostalgia and regret as he boarded the boat for America, knowing that he would probably never see his 'old world' again.
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agony -
Extreme physical or mental suffering
Max was in physical agony as he rode his bicycle up the long mountain trail, but spiritually and emotionally he was in heaven.
