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maniac - Someone who is mentally ill tending towards violent and dangerous behavior.

The film’s villain was portrayed as a ruthless maniac with no regard for human life.

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nuts - Crazy, insane, or stupid, often in a humorous way

Bill's friends thought he was nuts for swimming in the middle of the winter.

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loudmouth - Someone who speaks loudly and without thinking, often causing trouble or embarrassment.

Even though he was a real loudmouth, always bragging about his achievements and rarely listening to others, he was still amazingly successful.

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berserk - To behave in a wild and uncontrolled way as a result of something unexpected happening.

When Anne found out that she had lost all her money as a result of stock fraud, she went berserk, running around the house, screaming and breaking dishes.

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kooky - Strange and different, in a funny way

Salvador Dali's kooky appearance was only exceeded by his even more bizarre paintings.

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deranged - Behaving in an uncontrolled or dangerous way because of mental illness

Charles Manson led a group of followers who became mentally deranged as a result of taking too many psychedelic drugs

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loony - Crazy or silly

The patients in the mental hospital could be described as loony, but the doctors tried to treat them as normal human beings with normal problems in order to try to help them get better.

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hysterical - Having uncontrolled extreme emotion

When Amy found out that her house had been destroyed by the tornado, she broke down into hysterical crying, and could not be comforted for hours.

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batty - Mad and slightly crazy, usually in a humorous way

The computer system wouldn't let Greg log on or change his password, and it was driving him batty.

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unhinged - Mentally unbalanced and unstable

Trevor crossed the street when he saw the unhinged person yelling at him.

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crackpot - A slightly strange or foolish person

Wearing mismatched clothing and yelling to nobody in particular, the crackpot was amusing and ignored by the people who passed him by.

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compulsion - A strong, irresistible urge to do something, often against one's better judgement.

His gambling problem stemmed from a deep psychological compulsion.