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unsettling - Causing anxiety or uneasiness; disturbing.

She found it quite unsettling that often someone would ring the doorbell and then when she opened the door, there was nobody there.

adjective

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skittish - (of an animal, especially of a horse) excitable or easily scared

Bill's horse was especially skittish around people it didn't know, so they had to be careful when Bill's friend Fred wanted to stroke the horse's mane.

noun

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lapse - A temporary pause, omission, or failure

Becky's occasional lapses in memory as she got older worried her that it might be a condition that might get worse

noun

See verb

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gasp - A convulsive catching of breath

Abe let out a sharp gasp after he had remained underwater for ten seconds.

adjective

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jarring - Causing a sudden, unpleasant, or shocking effect.

The loud and sudden fire alarm was jarring in the otherwise quiet neighborhood.

noun

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fatigue - Extreme tiredness, typically resulting from mental or physical exertion or illness

After working for 15 hours straight, a strong cup of coffee did nothing to help Jolene's fatigue.

adjective

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chronic - Continuing or recurring frequently over time, Long-lasting and difficult to get rid of.

His chronic asthma requires daily medication.

adjective

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disconcerting - Making someone feel uncertain, uncomfortable or worried

Linda had a disconcerting habit of speaking before thinking about what she should say.

adjective

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stiff - Difficult to move one's body, often due to tightness or soreness; rigid or not easily bent; firm in structure.

The new shoes were stiff and uncomfortable at first.

verb

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fidget - To make small movements, especially of the hands and feet, through nervousness or impatience

Ron nervously fidgeted with his hands before giving the speech to 10,000 people.

adjective

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colicky - Having severe abdominal pain, often caused by spasm, obstruction, or distention of any of the hollow viscera, such as the intestines

Pam's crying baby was colicky because of intestinal problems.

adjective

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aggravating - Causing annoyance, irritation, and frustraton by repeated annoying behavior.

It’s so aggravating when people talk loudly during a movie.