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angst - A feeling of deep anxiety or dread, typically an unfocused one about the human condition or the state of the world in general

Edvard Munch's famous painting, "The Scream," is often viewed as an expression of angst in an uncertain world.

noun

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throes - Intense or violent pain and struggle, especially accompanying birth, death, or great change

Samantha experienced agonizing pain during the throes of childbirth.

adjective

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tragic - Something very sad often involving suffering.

The story of how Oedipus mistakenly killed his father and married his mother is a tragic story.

noun

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inflammation - A physical condition characterized by redness, heat, swelling, and pain, often as a response to injury or infection.

The redness of the big toe was caused by an infection, and the inflammation was visible and painful.

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ordeal - A painful or horrific experience, especially a protracted one

Knowing it was a fight to the death, the gladiator realized that this was an ordeal he would have to overcome if he wanted to survive.

noun

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anguish - Severe mental or physical pain or suffering

With her personal and professional life in disarray, Jenny's anguish was often too much for her to bear.

adjective

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afflicted - Suffering from a serious problem, illness, or pain, be it mental or physical.

Many people are afflicted with anxiety in high-pressure situations.

adjective

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humiliated - To feel ashamed after someone embarrasses you in front of others.

When Jim revealed to everyone at the party that Marty hadn't even finished 6th grade, Marty felt humiliated.

adjective

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exasperating - Intensely irritating; infuriating

Molly tried to enter the information in the online form, but she found the confusing directions so exasperating that she grabbed her own hair and screamed in frustration.

verb

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wince - Give a slight involuntary grimace or shrinking movement of the body out of or in anticipation of pain or distress

Tiger winced as he realized he had hit the ball too far beyond the hole.

nounverb noun

See verb

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burden - something you carry or withstand with much difficulty.

Financial debt can be a huge burden on families.

noun

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shackles - A device, such as a chain or cuff, designed to physically limit or control a person or thing's movement.

Shackles were placed on the prisoner's feet so that he would not be able to run away and escape.